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On November 23, 2010. Real Madrid CF qualified for the last 16 on Matchday 4 and can sew up first place in Group G with a point at AFC Ajax, who will have other ideas as they bid to close the gap on second-placed AC Milan.

AFC Ajax will hope to avenge their September defeat by Real Madrid CF and boost their hopes of progressing from Group G when the teams meet again on Matchday 5.

Section leaders Madrid secured their place in the competition's latter stages for the 14th year running when drawing at AC Milan on 3 November and another point will sew up top spot, while Ajax are looking to make up for their Matchday 4 defeat at AJ Auxerre.

Despite that loss, Ajax remain just a point short of second-placed Milan and will overtake them if they beat Madrid and the Rossoneri fail to win at Auxerre.